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Genes, Environments and Meta-Analysis
Figure 1. Application of Meta-GxE to Apoa2 locus. The forest plot (A) shows heterogeneity in the effect sizes across different studies. The PM- plot (B) predicts that 7 studies have an effect at this...
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The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of...
This year, we published a review of studies on the Hybrid Mouse Diversity Panel (HMDP) dataset, a project led by Aldons J. Lusis (David Geffen School of Medicine at UCLA). Our paper in Journal of...
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Identifying Genes Involved in Blood Cell Traits
In this study, blood cell traits were collected from each strain in the HMDP panel which consists of 100 mouse strains. Using EMMA[1], we identified associations with these traits. The main advantage...
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Review Article: Mixed Models and Population Structure
Mixed models are now widely used for association studies in order to correct for population structure. A simple intuitive description of how and why they work is provided in our Mouse GWAS review[1]...
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